Norvasc is also used to treat coronary artery disease (CAD) in patients without heart failure, and certain types of angina (chest pain) from CAD, such as activity- and stress-induced angina (chronic stable angina), and angina that occurs at rest (Prinzmetal’s angina).
Taken regularly, Norvasc can control angina, but it doesn’t stop chest pain after it has already begun.
The drug can also lower a person’s risk of cardiovascular events related to high blood pressure, such as strokes and heart attacks.
Norvasc belongs to a class of drugs called calcium channel blockers, which block the flow of calcium into heart muscles and the muscles along the walls of blood vessels.
Because the contraction of these muscles depends on calcium, Norvasc relaxes and widens blood vessels, thereby improving blood flow.
Doctors also sometimes prescribe Norvasc “off-label” for the treatment of cluster headaches, migraines, Raynaud’s syndrome (a blood vessel disorder), and congestive heart failure.
Manufactured by Pfizer, Norvasc was first approved by the Food and Drug Administration (FDA) in 1987.
In the early 1990s, researchers conducted the so-called PRAISE study, which was backed by Pfizer, to determine if Norvasc could help reduce the risk of death in people with severe heart failure.
Though the study found little overall benefits to severe heart failure patients, it suggested that Norvasc might prolong the life of a subgroup of people with heart failure from non-ischemic cardiomyopathy (cardiac muscle damage not associated with low blood supply to the coronary arteries).
To investigate this possibility, Pfizer-sponsored the PRAISE-2 study, which found no benefit to the subgroup in the PRAISE-1 trial and was presented at a conference in 2000.
However, results of the study weren’t published in an academic journal until 2013, leading some experts to question whether Pfizer intentionally delayed publication to prevent the data and findings from being publicly available.
Lisinopril is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is also used to treat heart failure and to improve survival after a heart attack. Lisinopril is an ACE inhibitor and works by relaxing blood vessels so that blood can flow more easily. OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. This medication may also be used to help protect the kidneys from harm due to diabetes.
Take this medication by mouth with or without food as directed by your doctor, usually once daily. If you are using the suspension form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. The dosage is based on your medical condition and response to treatment. For children, the dosage is also based on weight. Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. For the treatment of high blood pressure, it may take 2 to 4 weeks before you get the full benefit of this medication. For the treatment of heart failure, it may take weeks to months before you get the full benefit of this medication. Tell your doctor if your condition does not improve or if it worsens (such as your blood pressure readings remain high or increase).