Dapoxetine (Priligy)

Dapoxetine (Priligy)


Dapoxetine, also marketed as Priligy, is effective medicine used to treat premature ejaculation in men.

Dapoxetine (Priligy)  works by inhibiting the serotonin transporter, increasing serotonin’s action at the post synaptic cleft, and as a consequence promoting ejaculatory delay. As a member of selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant.

Premature ejaculation Randomized, double blind, placebo-controlled trials have confirmed the efficacy of dapoxetine for the treatment of PE. Different dosage has different impacts on different type of PE. Dapoxetine 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of dapoxetine 30 mg in men with lifelong PE, but there is no difference in men with acquired PE. Dapoxetine, given 1–3 hours before sexual episode, prolongs IELT, increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE. Since PE is associated with personal distress, interrelationship difficulty, dapoxetine provides help for men with PE to overcome this condition. Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE. Waldinger’s meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when dapoxetine is used. However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence increased of adverse effects such as decreasing sexual libido and causing erectile dysfunction. Dapoxetine, on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects

This medicine should be taken 1 – 2 hours before going to bed. It is believed to be the most effective drug that can treat PE problem quickly. People can get the immediate result after consuming this tablet. It should be consumed once a day to treat the PE problem. The effect of this medicine can last for up to 6 hours. Because of that reason, many men are interested to take this medicine for solving their sexual problem. There are two dosages of Dapoxetine that are commonly prescribed by most doctors. They are 30 mg and 60 mg of Dapoxetine. The dosage choice depends on someone”s health condition. Therefore, people need to consult with their doctors before taking this medicine.

The most common effects when taking dapoxetine are nausea, dizziness, dry mouth, headache, diarrhea, and insomnia. Discontinuation due to adverse effects is dose related. According to McMahon in recent study in Asia, the rate of discontinuation is 0.3%, 1.7%, and 5.3% of 1067 studied subjects with placebo, dapoxetine 30 mg, and dapoxetine 60 mg respectively. Unlike others SSRIs used to treat depression, which have been associated with high incidences of sexual dysfunction, dapoxetine is associated with low rates of sexual dysfunction. Taken as needed, dapoxetine has very mild adverse effects on loss of libido (<1%) and ED (<4%).
There are several patients who cannot take this medication because of their medical conditions. This drug is not recommended for people with lactose intolerance. This medicine can trigger the symptoms of lactose intolerance in some sensitive people. In most cases, Dapoxetine can cause digestive problems in people with this situation. When people consume Dapoxetine, they should reduce their driving activities. This medicine may cause some side effects, such as dizziness, blurred vision, reduced concentration, and some other problems. These health problems may reduce the ability to drive properly. In order to reduce the possibility of getting accidents, people need to avoid consuming this medicine before driving their vehicles. People with hypotension is not recommended to take this medicine. Dapoxetine may cause some adverse health problems, such as headache, nausea, dizziness, insomnia, fatigue, and some other problems. Therefore, people need to consult with their favorite doctors before taking this medicine. This medicine can be dangerous for people who have hypotension problem. It is recommended to consume this medication 1 – 2 times a day to treat the PE problem. When people miss a dosage from this medication, they should skip that dosage. It is important to follow the instructions from this medicine. It is not recommended to take this medicine more than the recommended dosage. There are some overdose symptoms that may be caused by this medicine, for example vomiting, nausea, agitation, dizziness, tremor, and some other health problems. It is okay to skip a dose without making up for the missed dose.
With phosphodiesterase inhibitors (PDE5 inhibitors) Many men that have PE also suffer from erectile dysfunction (ED). Treatment for these patients should consider the drug-drug interaction between dapoxetine and PDE5 inhibitors such as tadalafil (Cialis) or sildenafil (Viagra). In Dresser study (2006), plasma concentration of 24 subjects was obtained. Half of the sample pool were treated with dapoxetine 60 mg + tadalafil 20 mg; the other half were treated with dapoxetine 60 mg + sildenafil 100 mg. These plasma samples were then analyzed using liquid chromatography-tandem mass spectrometry. The results showed that dapoxetine does not alter the pharmacokinetic of tadalafil or sildenafil. With ethanol Ethanol doesn’t affect the pharmacokinetics of dapoxetine when taking concurrently with dapoxetine.