Mechanism of its action consists in relaxing of gut muscles at the cellular level. Colospa blocks transfer of Na+ through fast channels of myocyte into th cell and also inhibits calcium-depot replenishment, thus it performs a dual effect on bowels causing them to relax. It does not affect muscles of bronchi or uterus. No significant inhibition of normal peristalsis has been observed. This drug is used to treat a spasm of gastrointestinal organs (including due to organic disease), intestinal colic, biliary colic, irritable bowel syndrome (symptomatic treatment of pain and cramps, and intestinal disorders and discomfort) in adults. Dosage and directions Recommended daily dose of Colospa is 135 mg (1 tablet) 3 times daily, preferably before meals. Gradually the dosage may be reduced when the desired effect has been obtained.
This medication is a musculotropic antispasmodic agent without atropic, prescribed for irritable bowel syndrome, and GI tract spasm.